Most of the England players, including Buttler, are touring Pakistan for the first time. But the recalled Alex Hales, Moeen Ali and Liam Dawson have appeared in the Pakistan Super League.
Ben Stokes, Chris Jordan and Liam Livingstone have skipped the tour but are part of England’s T20 World Cup squad.
Buttler is recovering from a calf injury and is likely to missed some games. Ali is expected to lead the side in his absence.
“We’re in a bit of a unique situation with a few guys injured and will be fit in time for the World Cup, but not necessarily fit here,” Buttler said. “Obviously, the main aim for everyone is to turn up to Australia fully ready to go for that World Cup.”
England was due to play three T20s in Pakistan before the T20 World Cup in the United Arab Emirates last year, but cancelled the tour after New Zealand aborted its white-ball tour due to security concerns.
The ECB decision was described as disrespectful by the Pakistan Cricket Board, which worked tirelessly to convince other leading nations such as South Africa, West Indies, Bangladesh, Zimbabwe, Sri Lanka and Australia to tour after the 2009 terrorist attack on the Sri Lanka team in Lahore.
The port city of Karachi will hosts four T20Is from Sept. 20-25, and the remainder will be in Lahore from Sept. 28-Oct. 2.